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1

Inhibition of Acetylcholinesterase, β-Amyloid Aggregation, and NMDA Receptors in Alzheimer’s Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush

Simoni, Elena, Bartolini, Manuela, Cavalli, Andrea, Ceccarini, Luisa, Pascu, Nicoleta, McClymont, David W., Rosini, Michela, Tarozzi, Andrea, Bolognesi, Maria L., Minarini, Anna

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 152 KB

english, 2008

2

Evolution of histamine oxidase activity for biotechnological applications

Rosini, Elena, Tonin, Fabio, Vasylieva, Natalia, Marinesco, Stephane, Pollegioni, Loredano

Journal:

Applied Microbiology and Biotechnology

Year:

2014

Language:

english

File:

PDF, 404 KB

english, 2014

3

Preventing Bacterial Infections with Pilus‐Based Vaccines: the Group B Streptococcus Paradigm

Margarit, Immaculada, Rinaudo, Cira Daniela, Galeotti, Cesira L., Maione, Domenico, Ghezzo, Claudia, Buttazzoni, Elena, Rosini, Roberto, Runci, Ylenia, Mora, Marirosa, Buccato, Scilla, Pagani, Massimi

Journal:

The Journal of Infectious Diseases

Year:

2009

Language:

english

File:

PDF, 350 KB

english, 2009

4

Intrinsic antimicrobial properties of silk spun by genetically modified silkworm strains

Saviane, Alessio, Romoli, Ottavia, Bozzato, Andrea, Freddi, Giuliano, Cappelletti, Chiara, Rosini, Elena, Cappellozza, Silvia, Tettamanti, Gianluca, Sandrelli, Federica

Journal:

Transgenic Research

Year:

2018

Language:

english

File:

PDF, 6.35 MB

english, 2018

5

In vitro evolution of an l -amino acid deaminase active on l -1-naphthylalanine

Melis, Roberta, Rosini, Elena, Pirillo, Valentina, Pollegioni, Loredano, Molla, Gianluca

Journal:

Catalysis Science & Technology

Year:

2018

Language:

english

File:

PDF, 2.61 MB

english, 2018

6

Enzymatic Conversion of Unnatural Amino Acids by Yeast D-Amino Acid Oxidase

Antonio Caligiuri, Paola D'Arrigo, Elena Rosini, Davide Tessaro, Gianluca Molla, Stefano Servi, Loredano Pollegioni

Journal:

Advanced Synthesis & Catalysis

Year:

2006

Language:

english

File:

PDF, 334 KB

english, 2006

7

ChemInform Abstract: Exploiting the Lipoic Acid Structure in the Search for Novel Multitarget Ligands Against Alzheimer′s Disease.

Michela Rosini, Elena Simoni, Manuela Bartolini, Andrea Tarozzi, Riccardo Matera, Andrea Milelli, Patrizia Hrelia, Vincenza Andrisano, Maria Laura Bolognesi, Carlo Melchiorre

Journal:

Year:

2012

File:

PDF, 22 KB

2012

8

CASCAT: The Power of The Combined Protein Engineering Approach: Evolution of A Glycine Oxidase for A Novel Mechanism of Glyphosate Tolerance

Pollegioni Loredano, Pedotti Mattia, Rosini Elena, Molla Gianluca, Moschetti Tommaso

Journal:

Journal of Biotechnology

Year:

2010

Language:

english

File:

PDF, 91 KB

english, 2010

9

Production of Evolved Variants of D-Amino Acid Oxidase for A Cancer Enzyme Therapy

Elena, Rosini, Gianluca, Molla, Silvia, Sacchi, Loredano, Pollegioni

Journal:

Journal of Biotechnology

Year:

2010

Language:

english

File:

PDF, 73 KB

english, 2010

10

Properties and applications of microbialD-amino acid oxidases: current state and perspectives

Loredano Pollegioni, Gianluca Molla, Silvia Sacchi, Elena Rosini, Roberto Verga, Mirella S. Pilone

Journal:

Applied Microbiology and Biotechnology

Year:

2008

Language:

english

File:

PDF, 596 KB

english, 2008

11

Optimization of d-amino acid oxidase for low substrate concentrations – towards a cancer enzyme therapy

Elena Rosini, Loredano Pollegioni, Sandro Ghisla, Roberto Orru, Gianluca Molla

Journal:

Year:

2009

Language:

english

File:

PDF, 509 KB

english, 2009

12

On the reaction of d-amino acid oxidase with dioxygen: O2 diffusion pathways and enhancement of reactivity

Elena Rosini, Gianluca Molla, Sandro Ghisla, Loredano Pollegioni

Journal:

Year:

2011

Language:

english

File:

PDF, 468 KB

english, 2011

13

Evolution of an acylase active on cephalosporin C

Loredano Pollegioni, Simona Lorenzi, Elena Rosini, Giorgia Letizia Marcone, Gianluca Molla, Roberto Verga, Walter Cabri, Mirella S. Pilone

Journal:

Protein Science

Year:

2005

Language:

english

File:

PDF, 963 KB

english, 2005

14

Idiopathic bilateral facial palsy: is a causative role of anti-GM1 ganglioside and herpes simplex type 1 possible?

Elena Pretegiani, Francesca Rosini, Donatella Donati, Alessandra Rufa, Donatella Moschettini, Alfonso Cerase, Alessandra Morucci, Pasquale Annunziata, Antonio Federico

Journal:

Neurological Sciences

Year:

2012

Language:

english

File:

PDF, 235 KB

english, 2012

15

Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer’s disease

Michela Rosini, Elena Simoni, Manuela Bartolini, Andrea Tarozzi, Riccardo Matera, Andrea Milelli, Patrizia Hrelia, Vincenza Andrisano, Maria Laura Bolognesi, Carlo Melchiorre

Journal:

European Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 291 KB

english, 2011

16

Activity of yeast d-amino acid oxidase on aromatic unnatural amino acids

Antonio Caligiuri, Paola D’Arrigo, Elena Rosini, Giuseppe Pedrocchi-Fantoni, Davide Tessaro, Gianluca Molla, Stefano Servi, Loredano Pollegioni

Journal:

Journal of Molecular Catalysis B: Enzymatic

Year:

2008

Language:

english

File:

PDF, 307 KB

english, 2008

17

On the substrate preference of glutaryl acylases

Elena Rosini, Claudia Stella Monelli, Loredano Pollegioni, Sergio Riva, Daniela Monti

Journal:

Journal of Molecular Catalysis B: Enzymatic

Year:

2012

Language:

english

File:

PDF, 641 KB

english, 2012

18

Glycine oxidase from Bacillus subtilis: Role of Histidine 244 and Methionine 261

Angelo Boselli, Elena Rosini, Giorgia Letizia Marcone, Silvia Sacchi, Laura Motteran, Mirella S. Pilone, Loredano Pollegioni, Gianluca Molla

Journal:

Year:

2007

Language:

english

File:

PDF, 521 KB

english, 2007

19

Evaluating the human ongoing visual search performance by eye tracking application and sequencing tests

Giacomo Veneri, Elena Pretegiani, Francesca Rosini, Pamela Federighi, Antonio Federico, Alessandra Rufa

Journal:

Computer Methods and Programs in Biomedicine

Year:

2012

Language:

english

File:

PDF, 1.19 MB

english, 2012

20

Analyzing the d-amino acid content in biological samples by engineered enzymes

Luca Frattini, Elena Rosini, Loredano Pollegioni, Mirella S. Pilone

Journal:

Journal of Chromatography B

Year:

2011

Language:

english

File:

PDF, 481 KB

english, 2011

21

Expression of rat diamine oxidase in Escherichia coli

Elena Rosini, Serena Nossa, Mattia Valentino, Paola D’Arrigo, Stéphane Marinesco, Loredano Pollegioni

Journal:

Journal of Molecular Catalysis B: Enzymatic

Year:

2012

Language:

english

File:

PDF, 555 KB

english, 2012

22

P1-339: mtDNA inherited and somatic variability in Alzheimer’s disease

Aurelia Santoro, Elisa Balducci, Francesca Rosini, Alberto Montesanto, Stefano Salvioli, Giuseppina Rose, Elena Bellavista, Michele Mishto, Elena Bonora, Giuseppe Gasparre, Andrea Chiamenti, Giovanna

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 67 KB

english, 2006

23

A biosensor for all d-amino acids using evolved d-amino acid oxidase

Elena Rosini, Gianluca Molla, Carlo Rossetti, Mirella S. Pilone, Loredano Pollegioni, Silvia Sacchi

Journal:

Journal of Biotechnology

Year:

2008

Language:

english

File:

PDF, 628 KB

english, 2008

24

Cephalosporin C acylase: dream and(/or) reality

Pollegioni, Loredano, Rosini, Elena, Molla, Gianluca

Journal:

Applied Microbiology and Biotechnology

Year:

2013

Language:

english

File:

PDF, 905 KB

english, 2013

25

Evidence for Sub-Haplogroup H5 of Mitochondrial DNA as a Risk Factor for Late Onset Alzheimer's Disease

Santoro, Aurelia, Balbi, Valentina, Balducci, Elisa, Pirazzini, Chiara, Rosini, Francesca, Tavano, Francesca, Achilli, Alessandro, Siviero, Paola, Minicuci, Nadia, Bellavista, Elena, Mishto, Michele,

Journal:

Year:

2010

Language:

english

File:

PDF, 1.07 MB

english, 2010

26

The Bivalent Ligand Approach as a Tool for Improving the in vitro Anti-Alzheimer Multitarget Profile of Dimebon

Rosini, Michela, Simoni, Elena, Bartolini, Manuela, Soriano, Elena, Marco-Contelles, José, Andrisano, Vincenza, Monti, Barbara, Windisch, Manfred, Hutter-Paier, Birgit, McClymont, David W., Mellor, Ia

Journal:

Year:

2013

Language:

english

File:

PDF, 640 KB

english, 2013

27

Oxidative Stress in Alzheimer’s Disease: Are We Connecting the Dots?

Rosini, Michela, Simoni, Elena, Milelli, Andrea, Minarini, Anna, Melchiorre, Carlo

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1003 KB

english, 2014

28

Multi-target Design Strategies in the Context of Alzheimer’s Disease: Acetylcholinesterase Inhibition and NMDA Receptor Antagonism as the Driving Forces

Rosini, Michela, Simoni, Elena, Minarini, Anna, Melchiorre, Carlo

Journal:

Neurochemical Research

Year:

2014

Language:

english

File:

PDF, 833 KB

english, 2014

29

Visual System Involvement in CADASIL

Pretegiani, Elena, Rosini, Francesca, Dotti, Maria T., Bianchi, Silvia, Federico, Antonio, Rufa, Alessandra

Journal:

Journal of Stroke and Cerebrovascular Diseases

Year:

2013

Language:

english

File:

PDF, 839 KB

english, 2013

30

Eight and a Half Syndrome with Hemiparesis and Hemihypesthesia: The Nine Syndrome?

Rosini, Francesca, Pretegiani, Elena, Guideri, Francesca, Cerase, Alfonso, Rufa, Alessandra

Journal:

Journal of Stroke and Cerebrovascular Diseases

Year:

2013

Language:

english

File:

PDF, 233 KB

english, 2013

31

Prazosin-Related Compounds. Effect of Transforming the Piperazinylquinazoline Moiety into an Aminomethyltetrahydroacridine System on the Affinity for α 1 -Adrenoreceptors

Rosini, Michela, Antonello, Alessandra, Cavalli, Andrea, Bolognesi, Maria L., Minarini, Anna, Marucci, Gabriella, Poggesi, Elena, Leonardi, Amedeo, Melchiorre, Carlo

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 158 KB

english, 2003

32

Spatial ranking strategy and enhanced peripheral vision discrimination optimize performance and efficiency of visual sequential search

Veneri, Giacomo, Pretegiani, Elena, Fargnoli, Francesco, Rosini, Francesca, Vinciguerra, Claudia, Federighi, Pamela, Federico, Antonio, Rufa, Alessandra

Journal:

European Journal of Neuroscience

Year:

2014

Language:

english

File:

PDF, 762 KB

english, 2014

33

Multistep enzyme catalysed deracemisation of 2-naphthyl alanine

Caligiuri, Antonio, D'Arrigo, Paola, Gefflaut, Thierry, Molla, Gianluca, Pollegioni, Loredano, Rosini, Elena, Rossi, Cristina, Servi, Stefano

Journal:

Biocatalysis and Biotransformation

Year:

2006

Language:

english

File:

PDF, 94 KB

english, 2006

34

WB 4101-Related Compounds. 2. 1 Role of the Ethylene Chain Separating Amine and Phenoxy Units on the Affinity for α 1 -Adrenoreceptor Subtypes and 5-HT 1A Receptors

Bolognesi, Maria L., Budriesi, Roberta, Cavalli, Andrea, Chiarini, Alberto, Gotti, Roberto, Leonardi, Amedeo, Minarini, Anna, Poggesi, Elena, Recanatini, Maurizio, Rosini, Michela, Tumiatti, Vincenzo,

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 272 KB

english, 1999

35

Novel biosensors based on optimized glycine oxidase

Rosini, Elena, Piubelli, Luciano, Molla, Gianluca, Frattini, Luca, Valentino, Mattia, Varriale, Antonio, D'Auria, Sabato, Pollegioni, Loredano

Journal:

Year:

2014

Language:

english

File:

PDF, 956 KB

english, 2014

36

Strategic manipulation of an industrial biocatalyst - evolution of a cephalosporin C acylase

Conti, Gianluca, Pollegioni, Loredano, Molla, Gianluca, Rosini, Elena

Journal:

Year:

2014

Language:

english

File:

PDF, 821 KB

english, 2014

37

Immobilization of l -aspartate oxidase from Sulfolobus tokodaii as a biocatalyst for resolution of aspartate solutions

D'Arrigo, Paola, Allegretti, Chiara, Fiorati, Andrea, Piubelli, Luciano, Rosini, Elena, Tessaro, Davide, Valentino, Mattia, Pollegioni, Loredano

Journal:

Catalysis Science & Technology

Year:

2015

Language:

english

File:

PDF, 417 KB

english, 2015

38

Structure of a class III engineered cephalosporin acylase: comparisons with class I acylase and implications for differences in substrate specificity and catalytic activity

Golden, Emily, Paterson, Rachel, Tie, Wan Jun, Anandan, Anandhi, Flematti, Gavin, Molla, Gianluca, Rosini, Elena, Pollegioni, Loredano, Vrielink, Alice

Journal:

Biochemical Journal

Year:

2013

Language:

english

File:

PDF, 1.40 MB

english, 2013

39

One-pot conversion of cephalosporin C by using an optimized two-enzyme process

Conti, Gianluca, Pollegioni, Loredano, Rosini, Elena

Journal:

Catalysis Science & Technology

Year:

2015

Language:

english

File:

PDF, 1.13 MB

english, 2015

40

Lignin-degrading enzymes

Pollegioni, Loredano, Tonin, Fabio, Rosini, Elena

Journal:

Year:

2015

Language:

english

File:

PDF, 1.57 MB

english, 2015

41

Eye movement changes in mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)

Vinciguerra, Claudia, Federighi, Pamela, Rosini, Francesca, Pretegiani, Elena, Cardaioli, Elena, Dotti, Maria T., Sicurelli, Francesco, Federico, Antonio, Rufa, Alessandra

Journal:

Journal of the Neurological Sciences

Year:

2015

Language:

english

File:

PDF, 490 KB

english, 2015

42

[IEEE 2010 10th IEEE International Conference on Information Technology and Applications in Biomedicine (ITAB 2010) - Corfu, Greece (2010.11.3-2010.11.5)] Proceedings of the 10th IEEE International Conference on Information Technology and Applications in Biomedicine - Evaluating human visual search performance by Monte Carlo methods and heuristic model

Veneri, Giacomo, Pretegiani, Elena, Federighi, Pamela, Rosini, Francesca, Federico, Antonio, Rufa, Alessandra

Year:

2010

Language:

english

File:

PDF, 1.16 MB

english, 2010

43

An optimized polyamine moiety boosts the potency of human type II topoisomerase poisons as quantified by comparative analysis centered on the clinical candidate F14512

Palermo, Giulia, Minniti, Elirosa, Greco, Maria Laura, Riccardi, Laura, Simoni, Elena, Convertino, Marino, Marchetti, Chiara, Rosini, Michela, Sissi, Claudia, Minarini, Anna, De Vivo, Marco

Journal:

Chemical Communications

Year:

2015

Language:

english

File:

PDF, 2.14 MB

english, 2015

44

Unveiling the Atomic-Level Determinants of Acylase–Ligand Complexes: An Experimental and Computational Study

Mollica, Luca, Conti, Gianluca, Pollegioni, Loredano, Cavalli, Andrea, Rosini, Elena

Journal:

Journal of Chemical Information and Modeling

Year:

2015

Language:

english

File:

PDF, 6.47 MB

english, 2015

45

Multitarget-Directed Ligands: Innovative Chemical Probes and Therapeutic Tools Against Alzheimer's Disease

Laura Bolognesi, Maria, Simoni, Elena, Rosini, Michela, Minarini, Anna, Tumiatti, Vincenzo, Melchiorre, Carlo

Journal:

Current Topics in Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 348 KB

english, 2011

46

Identification of protective and broadly conserved vaccine antigens from the genome of extraintestinal pathogenicEscherichia coli

Danilo Gomes Moriel, Isabella Bertoldi, Angela Spagnuolo, Sara Marchi, Roberto Rosini, Barbara Nesta, Ilaria Pastorello, Vanja A. Mariani Corea, Giulia Torricelli, Elena Cartocci, Silvana Savino, Mari

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.44 MB

english, 2010

47

Cascade enzymatic cleavage of the β-O-4 linkage in a lignin model compound

Rosini, Elena, Allegretti, Chiara, Melis, Roberta, Cerioli, Lorenzo, Conti, Gianluca, Pollegioni, Loredano, D'Arrigo, Paola

Journal:

Catalysis Science & Technology

Year:

2016

Language:

english

File:

PDF, 1.04 MB

english, 2016

48

Comparison of different microbial laccases as tools for industrial uses

Tonin, Fabio, Melis, Roberta, Cordes, Arno, Sanchez-Amat, Antonio, Pollegioni, Loredano, Rosini, Elena

Journal:

New Biotechnology

Year:

2016

Language:

english

File:

PDF, 520 KB

english, 2016

49

Different recombinant forms of polyphenol oxidase A, a laccase from Marinomonas mediterranea

Tonin, Fabio, Rosini, Elena, Piubelli, Luciano, Sanchez-Amat, Antonio, Pollegioni, Loredano

Journal:

Protein Expression and Purification

Year:

2016

Language:

english

File:

PDF, 3.50 MB

english, 2016

50

Multitarget strategies in Alzheimer's disease: benefits and challenges on the road to therapeutics

Rosini, Michela, Simoni, Elena, Caporaso, Roberta, Minarini, Anna

Journal:

Future Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.59 MB

english, 2016

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